Detail for TRAIL-resistant glioma stem cells


Full Name

TRAIL-resistant glioma stem cells

Gene Name

Related Disease

  • Glioblastoma [ref.1]

Therapy Method

Function

TRAIL, a type-II transmembrane homotrimeric protein that belongs to the TNF gene superfamily, is a promising candidate for cancer therapy because of its selective apoptotic effect in a wide variety of transformed cells without affecting normal cells.
 
Combined treatment with NP-TRAIL and g-radiation or bortezomib sensitized TRAIL-resistant GSCs to NP-TRAIL.

Related Pathway/CSCs feature

Reference

  • [1] TRAIL conjugated to nanoparticles exhibits increased anti-tumor activities in glioma cells and glioma stem cells in vitro and in vivo.
    Perlstein, B., et al. (2013). "" Neuro Oncol 15(1): 29-40.. [ 23144078 ]

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