Detail for ILF3

Full Name

Interleukin enhancer-binding factor 3

Uniprot ID

Gene Name



Related Disease

  • Non-small cell lung cancer [ref.1]

Therapy Method


ILF3 (Interleukin Enhancer Binding Factor 3) is a Protein Coding gene. Diseases associated with ILF3 include Ovarian Mucinous Cystadenocarcinoma. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is STRBP.

ILF3 is a RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, ILF3 promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons, and plays a role in the back-splicing of a subset of circRNAs. Also ILF3 participates in a wide range of transcriptional and post-transcriptional processes.
It could binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs.

Related Pathway/CSCs feature

  • Enhanc the expressions of tumor survival-associated EGFR and other oncoproteins.


  • [1] EGFR-mediated interleukin enhancer-binding factor 3 contributes to formation and survival of cancer stem-like tumorspheres as a therapeutic target against EGFR-positive non-small cell lung cancer.
    Lung Cancer.2018 Feb;116:80-89. [ 29413056 ]

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