Detail for Glioblastoma stem cells


Full Name

Glioblastoma stem cells

Gene Name

-

Related Disease

  • Glioblastoma multiforme [ref.1]

Function

These cells that repopulate and maintain GBM tumors after gross surgical resection are thought to be undifferentiated glioblastoma stem cells (GSCs, PMID: 29204831). They are known to be a major cause of recurrence after conventional therapy because GSCs possess self-renewal ability, aberrant multi-lineage differentiation, and resistance to chemotherapy and radiotherapy. [1] Recent reports have shown that not only can GSCs differentiate into progenitor and terminal cells, but their daughter cells can also de-differentiate back into GSCs depending on microenvironmental cues and adaptation to treatment. Alternate cell surface markers such as integrin α6, SSEA-1, A2B5 and CD44 could also be considered to enrich for GSC population (PMID: 29204831).

Related Pathway/CSCs feature

  • Not Detected

Reference

  • [1] BRM270,A Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence.
    J Med Food.2017 Sep;20(9):838-845. [ 28792781 ]

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