Detail for TOPK

Full Name

T-LAK cell-originated protein kinase

Gene Name



Related Disease

  • small cell lung cancer [ref.1]

Therapy Method

  • [ref.]


PBK (PDZ Binding Kinase) is a Protein Coding gene. Diseases associated with PBK include Hematologic Cancer and Ewing Sarcoma. Among its related pathways are 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression and DNA Damage. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

Related Pathway/CSCs feature


  • [1] TOPK (T-LAK cell-originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancer.
    Cancer Sci.2017 Mar;108(3):488-496. [ 28075524 ]

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