Detail for S100B


Full Name

S100 Calcium Binding Protein B

Uniprot ID

Gene Name

S100B

NCBI ID

Related Disease

  • Ovarian cancer [ref.1]

Therapy Method

Function

S100B (S100 Calcium Binding Protein B) is a Protein Coding gene. Diseases associated with S100B include Middle Cerebral Artery Infarction and Amelanotic Melanoma. Among its related pathways are Activated TLR4 signalling and Advanced glycosylation endproduct receptor signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is S100A1.

S100B is one of the members of the S100 protein family and is involved in the progression of avariety of cancers. Increasing S100B levels indicatestumor progression, while decreasing S100B levels implies arespon se to therapy (PMID: 12569284). As an unreported inflammatory cytokine in CSLCs (Cancer stem-like cells), S100B is the most abundantly expressedfactor in CSLCs compared with non-CSLCs.

S100B is one of the members of the S100 protein family and is involved in the progression of a
variety of cancers
S100B is one of the members of the S100 protein family and is involved in the progression of a
variety of cancers.
S100B is one of the members of the S100 protein family and is involved in the progression of a
variety of cancers.

Related Pathway/CSCs feature

  • Not Detected

Reference

  • [1] S100B Mediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53.
    Stem Cells.2017 Feb;35(2):325-336. [ 27501952 ]

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