Detail for PDK1

Full Name

pyruvate dehydrogenase kinase 1

Gene Name



Related Disease

  • glioma [ref.1]

Therapy Method

  • [ref.]


PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Chronic Mountain Sickness. Among its related pathways are Central carbon metabolism in cancer and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include protein kinase activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. An important paralog of this gene is PDK2.

Related Pathway/CSCs feature


  • [1] SOX9-PDK1 axis is essential for glioma stem cell self-renewal and temozolomide resistance.
    Oncotarget.2017 Nov 30;9(1):192-204. [ 29416606 ]

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