Detail for PBX3

Full Name

PBX Homeobox 3

Gene Name



Related Disease

  • MLL-rearranged leukemia [ref.1]

Therapy Method

  • [ref.]


PBX3 (PBX Homeobox 3) is a Protein Coding gene. Diseases associated with PBX3 include Childhood Pilocytic Astrocytoma and Pilocytic Astrocytoma. Among its related pathways are Transcriptional misregulation in cancer and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is PBX1.

Related Pathway/CSCs feature


  • [1] PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia.
    Int J Cancer.2017 Jul 15;141(2):324-335. [ 28411381 ]

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