Detail for miRNA-19b/20a/92a


Full Name

MicroRNA 19b/20a/92a

Gene Name

MIR19B1, MIR20A, MIR92A2

Related Disease

  • Gastric cancer [ref.1]
  • Lung cancer [ref.2]

Therapy Method

Function

miRNA-19b/20a/92a facilitated the self-renewal of gastric cancer stem cells (GCSCs) by targeting E2F1 and HIPK1 on the post-transcriptional level and activating the β-catenin signal transduction pathway. miRNA-92a was an independent factor and index predicting the prognosis of gastric cancer.

Related Pathway/CSCs feature

Reference

  • [1] In vitro and in vivo effects of miRNA-19b/20a/92a on gastric cancer stem cells and the related mechanism.
    Int J Med Sci.2018 Jan 1;15(1):86-94. [ 29333091 ]
  • [2] miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.
    J Nutr Biochem.2017 Jun;44:80-91.. [ 28431267 ]

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