Detail for CD133high/CD44low/CD199 cells

Full Name

CD133high/CD44low/CD199 osteosarcoma cells

Gene Name

Related Disease

  • Osteosarcoma [ref.1]

Therapy Method


In culture conditions known to be permissive for stem cell differentiation, the cancer stem cells treated with bufalin failed to attach to the flask and maintained a high-level expression of stem cell marker CD133 and OCT-4 and a low level expression of fibronectin, which facilitated the metastasis of cancer.

Related Pathway/CSCs feature


  • [1] Bufalin inhibits the differentiation and proliferation of human osteosarcoma cell line hMG63-derived cancer stem cells.
    Chang, Y., et al. (2014). Tumour Biol 35(2): 1075-1082.. [ 24006225 ]

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