Detail for miR-30-5p


Full Name

MicroRNA-30-5p

Gene Name

MIR30A

NCBI ID

Related Disease

  • Colorectal cancer [ref.1]

Therapy Method

Function

MicroRNAs (miRNAs) are a class of highly conserved and endogenously synthesized gene expression regulators, which are single stranded, non-coding RNA molecules typically 18 to 22 nucleotides long in mature form. miRNAs are found throughout the body, and their expression is coordinated with that of coding genes, enabling them to regulate diverse and complex cellular pathways. MicroRNAs dysregulation can disrupt the balance of cell signaling and growth processes, resulting in disease such as cancer. Nowadays, several miRNAs have been found to be aberrantly expressed in distinct types of human cancers. By targeting cancer associated genes, some miRNAs behave as either tumor suppressors or oncogenes, and changes in their expression are associated with tumor initiation, progression and/or metastasis.

MiR‐30‐5p could target the Wnt/β‐catenin signaling pathway as a tumor suppressor. 

Related Pathway/CSCs feature

Reference

  • [1] MiR-30-5p suppresses cell chemoresistance and stemness in colorectal cancer through USP22/Wnt/β-catenin signaling axis.
    J Cell Mol Med.2018 Oct 19. doi: 10.1111/jcmm.13968. [ 30338942 ]

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