This MicroRNA sequence maps to human chromosome 17. miR-196 family are expressed from HOX gene clusters in mammals, and that HOX genes in these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directed cleavage through a perfectly complementary miR-target site. Other HOX genes have imperfect miR-196 complementary sites indicative of regulation by translational repression. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies.
Related Pathway/CSCs feature
 miR-196a-5p modulates gastric cancer stem cell characteristics by targeting Smad4.
Int J Oncol.2017 Jun;50(6):1965-1976. [ 28440445 ]