Detail for MicroRNA-196a-5p


Full Name

MicroRNA-196a-5p

Gene Name

hsa-miR-196a

Related Disease

  • Gastric cancer [ref.1]

Therapy Method

Function

This MicroRNA sequence maps to human chromosome 17. miR-196 family are expressed from HOX gene clusters in mammals, and that HOX genes in these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directed cleavage through a perfectly complementary miR-target site. Other HOX genes have imperfect miR-196 complementary sites indicative of regulation by translational repression. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies.

Related Pathway/CSCs feature

  • -

Reference

  • [1] miR-196a-5p modulates gastric cancer stem cell characteristics by targeting Smad4.
    Int J Oncol.2017 Jun;50(6):1965-1976. [ 28440445 ]

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