Detail for EMP2


Full Name

Epithelial membrane protein-2

Gene Name

EMP2

NCBI ID

Related Disease

  • Endometrial cancer [ref.1]

Therapy Method

Function

EMP2 (Epithelial Membrane Protein 2) is a Protein Coding gene. Diseases associated with EMP2 include Nephrotic Syndrome, Type 10 and Idiopathic Steroid-Sensitive Nephrotic Syndrome With Minimal Change. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase binding. An important paralog of this gene is PMP22.

Epithelial membrane protein-2 (EMP2), a tetraspan protein from the GAS-3/PMP22 family, is found in both endometrioid and serous endometrial cancers. Mechanistically, EMP2 regulates integrin-FAK activation driving both tumor migration as well as HIF-1α mediated angiogenesis, and interestingly, these are both pathways linked into the formation of cancer stem cells. Growing evidence in endometrial cancer suggests that EMP2 is an oncogenic protein whose expression directly contributes to tumor initiation and growth, and within patient samples increased EMP2 correlates with increased lymphovascular invasion as well as poor survival. [1]

Related Pathway/CSCs feature

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Reference

  • [1] EMP2 is a novel therapeutic target for endometrial cancer stem cells.
    Oncogene.2017 Oct 19;36(42):5793-5807. [ 28604744 ]

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