Detail for CD90


Full Name

Thy-1 membrane glycoprotein

Uniprot ID

Gene Name

THY1

NCBI ID

Related Disease

  • Glioblastoma [ref.1]

Therapy Method

Function

THY1 (Thy-1 Cell Surface Antigen) is a Protein Coding gene. Diseases associated with THY1 include Thymoma and Warthin Tumor. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein kinase binding and GTPase activator activity.

Thy-1 (CD90), a 25-37 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein on the external leaflet of the lipid bilayer, localizes to lipid rafts. It is expressed on many cell types including neuronal cells, thymocytes, lymphocytes, fibroblasts, activated endothelial cells, keratinocytic stem cells, hematopoietic and mesenchymal stem cells (MSCs), ovarian follicular cells, and some cancer cells. Recent studies have introduced CD90 as a marker for cancer stem cells (CSCs) in various malignancies. It has been reported that Thy-1 is involved in oncogenesis, T cell activation, apoptotic signaling, inhibition of neurite outgrowth, leukocyte and melanoma cell adhesion and migration, fibroblast proliferation, tumor suppression, and cell death.

Related Pathway/CSCs feature

Reference

  • [1] Selection and Evaluation of Specific Single Chain Antibodies against CD90, a Marker for Mesenchymal and Cancer Stem Cells.
    Rep Biochem Mol Biol.2018 Oct;7(1):45-51. [ 30324117 ]

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