Detail for ASB4


Full Name

Ankyrin repeat and SOCS box protein 4

Uniprot ID

Gene Name

ASB4

NCBI ID

Related Disease

  • Colorectal Cancer [ref.1]

Therapy Method

Function

ASB4 (Ankyrin Repeat And SOCS Box Containing 4) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include enzyme binding and ubiquitin protein ligase binding. An important paralog of this gene is ASB18.

ASB4 is probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism 

Related Pathway/CSCs feature

  • -

Reference

  • [1] The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer.
    Cancer Immunol Res.2018 Jan 25. [ 29371260 ]

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