Detail for STAT3


Full Name

Signal transducer and activator of transcription 3

Gene Name

GC17M042313

NCBI ID

Related Disease

  • Breast Cancer [ref.1]
  • hepatocellular carcinoma [ref.2]
  • glioblastoma multiforme [ref.3]
  • Gastric Cancer [ref.4]
  • osteosarcoma [ref.5]

Therapy Method

  • [ref.]

Function

STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Autoimmune Disease, Multisystem, Infantile-Onset, 1 and Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant. Among its related pathways are EGF/EGFR Signaling Pathway and Transcriptional Regulatory Network in Embryonic Stem Cell. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT1.

Related Pathway/CSCs feature

Reference

  • [1] STAT3 in Breast Cancer Onset and Progression: A Matter of Time and Context.
    Int J Mol Sci.2018 Sep 18;19(9).pii: E2818. [ 30231553 ]
  • [2] Gankyrin induces STAT3 activation in tumor microenvironment and sorafenib resistance in hepatocellular carcinoma.
    Cancer Sci.2017 Oct;108(10):1996-2003. [ 28777492 ]
  • [3] The role of STAT3 in glioblastoma progression through dual influences on tumor cells and the immune microenvironment.
    Mol Cell Endocrinol.2017 Aug 15;451:53-65. [ 28089821 ]
  • [4] STAT3 is Overactivated in Gastric Cancer Stem-Like Cells.
    Cell J.2016 Winter;17(4):617-28. [ 26862521 ]
  • [5] STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma.
    Cancer Lett.2012 Dec 1;325(1):80-8. [ 22743617 ]

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