Detail for IL-6


Full Name

interleukin-6

Gene Name

GC07P022765

NCBI ID

Related Disease

  • breast cancer [ref.1]
  • lung cancer [ref.2]

Therapy Method

  • [ref.]

Function

IL6 (Interleukin 6) is a Protein Coding gene. Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity.

Related Pathway/CSCs feature

Reference

  • [1] Tumor-derived mesenchymal-stem-cell-secreted IL-6 enhances resistance to cisplatin via the STAT3 pathway in breast cancer.
    Oncol Lett.2018 Jun;15(6):9142-9150. [ 29844821 ]
  • [2] IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation.
    Int J Cancer.2015 Feb 1;136(3):547-59. [ 24947242 ]

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