Detail for HIFs

Full Name

hypoxia-inducible factors

Gene Name



Related Disease

  • breast cancer [ref.1]
  • PAN [ref.2]

Therapy Method

  • [ref.]


SETD2 (SET Domain Containing 2) is a Protein Coding gene. Diseases associated with SETD2 include Luscan-Lumish Syndrome and Sotos Syndrome 1. Among its related pathways are Chromatin organization and PKMTs methylate histone lysines. Gene Ontology (GO) annotations related to this gene include histone-lysine N-methyltransferase activity. An important paralog of this gene is ASH1L.

Related Pathway/CSCs feature


  • [1] ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models.
    Mol Cancer.2016 Mar 22;15:26. [ 27001172 ]
  • [2] HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression.
    Carcinogenesis.2013 Aug;34(8):1699-707. [ 23740838 ]

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