Detail for CXCR4


Full Name

chemokine C-X-C motif receptor 4

Gene Name

GC02M136114

NCBI ID

Related Disease

  • breast cancer [ref.1,3]
  • PAN [ref.2]

Therapy Method

  • [ref.]

Function

CXCR4 (C-X-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CXCR4 include Whim Syndrome and Aids Dementia Complex. Among its related pathways are Akt Signaling and Development Angiotensin activation of ERK. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is CCR4.

Related Pathway/CSCs feature

Reference

  • [1] Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells.
    Biochim Biophys Acta Mol Basis Dis.2018 Nov;1864(11):3837-3846. [ 30251699 ]
  • [2] CXCR4 as biomarker for radioresistant cancer stem cells.
    Int J Radiat Biol.2014 Aug;90(8):687-99. [ 24650104 ]
  • [3] Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells.
    Biochim Biophys Acta Mol Basis Dis.2018 Nov;1864(11):3837-3846. [ 30251699 ]

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