Detail for TNF-R1


Full Name

TNF receptor-1

Gene Name

GC12M006308

NCBI ID

Related Disease

  • glioblastoma [ref.1]

Therapy Method

  • [ref.]

Function

TNFRSF1A (TNF Receptor Superfamily Member 1A) is a Protein Coding gene. Diseases associated with TNFRSF1A include Periodic Fever, Familial, Autosomal Dominant and Multiple Sclerosis 5. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF25.

Related Pathway/CSCs feature

Reference

  • [1] Endothelial expression of TNF receptor-1 generates a proapoptotic signal inhibited by integrin α6β1 in glioblastoma.
    Cancer Res.2012 Mar 15;72(6):1428-37. [ 22396498 ]

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