Detail for SREBP


Full Name

Sterol regulatory element-binding protein

Gene Name

GC17M017810

NCBI ID

Related Disease

  • glioblastoma multiforme [ref.1]

Therapy Method

  • [ref.]

Function

SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1) is a Protein Coding gene. Diseases associated with SREBF1 include Fatty Liver Disease and Smith-Magenis Syndrome. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Adipogenesis. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is SREBF2.

Related Pathway/CSCs feature

Reference

  • [1] SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme.
    Oncogene.2015 Oct 1;34(40):5128-40. [ 25619842 ]

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