Detail for SPARC

Full Name

Secreted Protein Acidic and Rich in Cysteine

Gene Name



Related Disease

  • Prostate cancer [ref.1]

Therapy Method

  • [ref.]


SPARC (Secreted Protein Acidic And Cysteine Rich) is a Protein Coding gene. Diseases associated with SPARC include Osteogenesis Imperfecta, Type Xvii and Osteogenesis Imperfecta, Type Iv. Among its related pathways are Cell adhesion_ECM remodeling and ECM proteoglycans. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is SPARCL1.

Related Pathway/CSCs feature


  • [1] Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone.
    J Biol Chem.2016 Sep 9;291(37):19351-63. [ 27422817 ]

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