Detail for PKM2


Full Name

The M2 isoform of glycolytic enzyme pyruvate kinase

Gene Name

GC15M072199

NCBI ID

Related Disease

  • lung cancer [ref.1]

Therapy Method

  • [ref.]

Function

PKM (Pyruvate Kinase M1/2) is a Protein Coding gene. Diseases associated with PKM include Pyruvate Kinase Deficiency Of Red Cells and Pigmentation Disease. Among its related pathways are Central carbon metabolism in cancer and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is PKLR.

Related Pathway/CSCs feature

Reference

  • [1] Enhanced expression of PKM2 associates with the biological properties of cancer stem cells from A549 human lung cancer cells.
    Oncol Rep.2017 Apr;37(4):2161-2166. [ 28259998 ]

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