Detail for LGR5

Full Name

Leucine Rich Repeat Containing G Protein-Coupled Receptor 5

Gene Name



Related Disease

  • colorectal tumour [ref.1]

Therapy Method

  • [ref.]


LGR5 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 5) is a Protein Coding gene. Diseases associated with LGR5 include Ankyloglossia and Colon Adenoma. Among its related pathways are Signaling by Wnt and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is LGR6.

Related Pathway/CSCs feature


  • [1] Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells.
    Br J Cancer.2015 Feb 17;112(4):714-9. [ 25611300 ]

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