Detail for KEAP1


Full Name

Kelch-like ECH-associated protein 1

Gene Name

GC19M010457

NCBI ID

Related Disease

  • lung cancer [ref.1]

Therapy Method

  • [ref.]

Function

KEAP1 (Kelch Like ECH Associated Protein 1) is a Protein Coding gene. Diseases associated with KEAP1 include Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors and Lung Papillary Adenocarcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Translational Control. Gene Ontology (GO) annotations related to this gene include transcription factor binding. An important paralog of this gene is KLHL20.

Related Pathway/CSCs feature

Reference

  • [1] Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment.
    Cell Metab.2018 Apr 3;27(4):935-943.e4. [ 29526543 ]

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