Detail for ITGB5


Full Name

Integrin beta-5

Uniprot ID

Gene Name

ITGB5

NCBI ID

Related Disease

  • Breast cancer [ref.1]

Therapy Method

Function

ITGB5 (Integrin Subunit Beta 5) is a Protein Coding gene. Diseases associated with ITGB5 include Villous Adenocarcinoma and Arrhythmogenic Right Ventricular Cardiomyopathy. Among its related pathways are ERK Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include integrin binding. An important paralog of this gene is ITGB3.

Integrins, heterodimeric trans-membrane matrix receptors, are major mediators of cell adhesion to ECM and ECM-induced intracellular signaling. Several β-integrins of the αv-β-family, including β1, β3 and β5, have been linked to invasion, epithelial-mesenchymal transition and cancer-stem cell biology. Integrin levels are frequently elevated in aggressive tumors, making these proteins attractive targets for therapy. Integrin β5 contributes to the transforming growth factor β (TGF-β)- induced EMT, tumor angiogenesis and resistance to radio- and chemotherapy.

Reference

  • [1] Integrin β5 contributes to the tumorigenic potential of breast cancer cells through the Src-FAK and MEK-ERK signaling pathways.
    Oncogene.2013 Jun 20;32(25):3049-58. [ 22824793 ]

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