Detail for ILK


Full Name

Integrin-linked protein kinase

Uniprot ID

Gene Name

ILK

NCBI ID

Related Disease

  • Multiple myeloma [ref.1]

Therapy Method

Function

ILK (Integrin Linked Kinase) is a Protein Coding gene. Diseases associated with ILK include Scar Contracture and Anaplastic Thyroid Cancer. Among its related pathways are ERK Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FPGT-TNNI3K.

Integrin-linked kinase (ILK) was first described as a serine/threonine protein kinase that binds directly to, and transduces signals from, β1 integrin subunits, which appeared to require the interaction of integrin cytoplasmic domains with cellular proteins. ILK is associated with multiple cellular functions including cell migration, cell proliferation, cell adhesions and signal transduction. 

Reference

  • [1] ILK promotes angiogenic activity of mesenchymal stem cells in multiple myeloma.
    Oncol Lett.2018 Jul;16(1):1101-1106. [ 29963187 ]

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