Detail for IDO1


Full Name

Indoleamine 2,3-Dioxygenase 1

Uniprot ID

Gene Name

IDO1

NCBI ID

Related Disease

  • Medulloblastoma [ref.1]

Therapy Method

Function

IDO1 (Indoleamine 2,3-Dioxygenase 1) is a Protein Coding gene. Diseases associated with IDO1 include Chlamydia and Listeriosis. Among its related pathways are African trypanosomiasis and Metabolism. Gene Ontology (GO) annotations related to this gene include heme binding and tryptophan 2,3-dioxygenase activity. An important paralog of this gene is IDO2.

IDO1 catalyzes the first ratelimiting step in the consumption of TRP. IDO1- mediated TRP depletion from tissues alters inflammation, as well as T-cell mediated immune response, in a variety of pathological settings, including cancer and, in particular, brain tumors.

Related Pathway/CSCs feature

Reference

  • [1] IDO1 involvement in mTOR pathway: a molecular mechanism of resistance to mTOR targeting in medulloblastoma.
    Oncotarget.2016 Aug 16;7(33):52900-52911. [ 27174915 ]

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