Detail for ICAM-1


Full Name

Intercellular adhesion molecule 1

Uniprot ID

Gene Name

ICAM1

NCBI ID

Related Disease

  • Breast cancer [ref.1]

Therapy Method

Function

ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ICAM1 include Malaria and Leukostasis. Among its related pathways are Rheumatoid arthritis and LDL Oxidation in Atherogenesis. An important paralog of this gene is ICAM3.

Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor (TNF) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues.[10] LFA-1 has also been found in a soluble form, which seems to bind and block ICAM-1.

Reference

  • [1] Breast cancer cells compete with hematopoietic stem and progenitor cells for intercellular adhesion molecule 1-mediated binding to the bone marrow microenvironment.
    Carcinogenesis.2016 Aug;37(8):759-767. [ 27207667 ]

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