Detail for HSP47


Full Name

Serpin H1

Uniprot ID

Gene Name

SERPINH1

NCBI ID

Related Disease

  • Gliomas [ref.1]

Therapy Method

Function

SERPINH1 (Serpin Family H Member 1) is a Protein Coding gene. Diseases associated with SERPINH1 include Osteogenesis Imperfecta, Type X and Preterm Premature Rupture Of The Membranes. Among its related pathways are Collagen chain trimerization and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

HSP47 is a heat-inducible protein encoded by SERPINH1 gene, which locates at chromosome 11q13.5, one of the most frequently amplified regions in human cancer(5). HSP47 is a member of the serpin superfamily of serine proteinase 
inhibitors which serve as a human chaperone protein for collagen. The overexpression of HSP47 has been detected in several tumor tissues including gliomas

Related Pathway/CSCs feature

  • -

Reference

  • [1] HSP47 Promotes Glioblastoma Stemlike Cell Survival by Modulating Tumor Microenvironment Extracellular Matrix through TGF-β Pathway.
    ACS Chem Neurosci.2017 Jan 18;8(1):128-134. [ 27696866 ]

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