Detail for Fibronectin


Full Name

Fibronectin

Uniprot ID

Gene Name

FN1

NCBI ID

Related Disease

  • Endometrial Cancer [ref.1]

Therapy Method

Function

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.
Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Reference

  • [1] The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells.
    Kusunoki, S., et al. (2013). Gynecol Oncol 129(3): 598-605.. [ 23500085 ]

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