Mesenchymal stem cells (also mesenchymal stromal cells, MSCs) are connective tissue progenitor cells that contribute to fibrotic reactions during tissue remodeling and repair in places of wounding and inflammation. In response to chemokines from tumor cells, MSCs are continuously recruited to and become integral components of the tumour microenvironment. MSCs in tumor microenvironment have been shown to exert influence on multiple hallmarks of cancer including resistance to chemotherapy. Therefore, MSCs seem to act as “co-conspirators” within the tumor microenvironment, protecting cancer cells from chemotherapy. However, little has been done to investigate the detrimental effects of MSCs in chemotherapeutic resistance of breast cancers.
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