Detail for DKK1


Full Name

Dickkopf-related protein 1

Uniprot ID

Gene Name

DKK1

NCBI ID

Related Disease

  • Myeloma [ref.1]

Therapy Method

Function

DKK1 (Dickkopf WNT Signaling Pathway Inhibitor 1) is a Protein Coding gene. Diseases associated with DKK1 include Chiari Malformation Type I and Osteoporosis, Juvenile. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and low-density lipoprotein particle receptor binding. An important paralog of this gene is DKK2.

It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 (Dkk1) is a protein-coding gene that acts from the anterior visceral endoderm. The dickkopf protein encoded by DKK1 is an antagonist of the Wnt/β-catenin signalling pathway that acts by isolating the LRP6 co-receptor so that it cannot aid in activating the WNT signaling pathway. DKK1 is also demonstrated to antagonize the Wnt/β-catenin pathway via a reduction in β-catenin and an increase in OCT4 expression.

Related Pathway/CSCs feature

Reference

  • [1] Chemotherapy-induced Dkk-1 expression by primary human mesenchymal stem cells is p53 dependent.
    Med Oncol.2016 Oct;33(10):113. [ 27586146 ]

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