DCLK1 (Doublecortin Like Kinase 1) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and Neuroscience. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DCLK2.
Doublecortin-like kinase 1 (DCLK1) is a validated gastro-intestinal TSC marker correlated to initiation, EMT, and pro-gression. Moreover, tumor-speciﬁc expression andextracellular isoform localization make DCLK1 viable for tar-geted therapies
Related Pathway/CSCs feature
 Alternative splice variants of DCLK1 mark cancer stem cells,promote self-renewal and drug-resistance,and can be targeted to inhibit tumorigenesis in kidney cancer.
Int J Cancer.2018 Sep 1;143(5):1162-1175. [ 29577277 ]