Detail for DCLK1


Full Name

Doublecortin-like kinase 1

Uniprot ID

Gene Name

DCLK1

NCBI ID

Related Disease

  • Renal cell carcinoma [ref.1]

Therapy Method

Function

DCLK1 (Doublecortin Like Kinase 1) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and Neuroscience. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DCLK2.

Doublecortin-like kinase 1 (DCLK1) is a validated gastro-intestinal TSC marker correlated to initiation, EMT, and pro-gression. Moreover, tumor-specific expression andextracellular isoform localization make DCLK1 viable for tar-geted therapies

Related Pathway/CSCs feature

  • -

Reference

  • [1] Alternative splice variants of DCLK1 mark cancer stem cells,promote self-renewal and drug-resistance,and can be targeted to inhibit tumorigenesis in kidney cancer.
    Int J Cancer.2018 Sep 1;143(5):1162-1175. [ 29577277 ]

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