Detail for CCL2


Full Name

C-C motif chemokine 2

Uniprot ID

Gene Name

CCL2

NCBI ID

Related Disease

  • breast cancer [ref.1]

Therapy Method

Function

CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with CCL2 include Neural Tube Defects and Human Immunodeficiency Virus Type 1. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include protein kinase activity and heparin binding. An important paralog of this gene is CCL7.

CCL2 is a monomeric polypeptide, with a molecular weight of approximately 13-15 kDa depending on levels of glycosylation. CCL2 is anchored in the plasma membrane of endothelial cells by glycosaminoglycan side chains of proteoglycans. CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. Platelet derived growth factor is a major inducer of CCL2 gene.CCR2 and CCR4 are two cell surface receptors that bind CCL2.

Reference

  • [1] CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells.
    Cancer Res.2012 Jun 1;72(11):2768-79. [ 22472119 ]

Back to top