Detail for BMP4/TSP1


Full Name

Bone morphogenetic protein 4, Thrombospondin-1

Uniprot ID

Gene Name

BMP4|THBS1

NCBI ID

Related Disease

  • Cervical cancer [ref.1]
  • Lung cancer [ref.1]
  • Murine melanoma [ref.1]

Therapy Method

Function

BMP4 (Bone Morphogenetic Protein 4) is a Protein Coding gene. Diseases associated with BMP4 include Microphthalmia, Syndromic 6 and Orofacial Cleft 11. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and heparin binding. An important paralog of this gene is BMP2.THBS1 (Thrombospondin 1) is a Protein Coding gene. Diseases associated with THBS1 include Thrombotic Thrombocytopenic Purpura and Posterior Uveal Melanoma. Among its related pathways are Focal Adhesion and TGF-beta signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS2.

BMP4 can directly exert an effect on cancer cells themselves, or on CSCs, inducing growth inhibition, cell cycle arrest, senescence, apoptosis or differentiation. 
The thrombospondin-1 protein is a member of the thrombospondin family. It is a multi-domain matrix glycoprotein that has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. 

Reference

  • [1] BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors.
    Oncogene.2014 Jul 17;33(29):3803-11. [ 24013228 ]

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