Detail for bFGF


Full Name

Fibroblast growth factor 2

Uniprot ID

Gene Name

FGF2

NCBI ID

Related Disease

  • Breast cancer [ref.1]

Therapy Method

Function

FGF2 (Fibroblast Growth Factor 2) is a Protein Coding gene. Diseases associated with FGF2 include Kaposi Sarcoma and Corneal Neovascularization. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and heparin binding. An important paralog of this gene is FGF1.

bFGF, which belongs to the heparin binding growth factor family, mediates various cellular events, including proliferation, motility, and differentiation. bFGF increases embryonic myogenic cell migration in a dose-dependent manner. bFGF also plays an important role in the proliferation and stem cell plasticity of adipose-derived stem cells. Furthermore, bFGF can activate normal fibroblasts and give them properties that are analogous to those of CAFs

Reference

  • [1] bFGF Promotes Migration and Induces Cancer-Associated Fibroblast Differentiation of Mouse Bone Mesenchymal Stem Cells to Promote Tumor Growth.
    Stem Cells Dev.2016 Sep 12. [ 27484709 ]

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