Detail for ALCAM (CD166)


Full Name

Activated leukocyte cell adhesion molecule

Uniprot ID

Gene Name

ALCAM

NCBI ID

Related Disease

  • subcutaneous tumours [ref.1]

Therapy Method

Function

ALCAM (Activated Leukocyte Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with ALCAM include Small Intestinal Adenocarcinoma. Among its related pathways are Developmental Biology and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is BCAM.

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands. CD166 protein expression is upregulated in a cell line deriving from a metastasizing melanoma. CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.

Related Pathway/CSCs feature

Reference

  • [1] Targeting ALCAM in the cryo-treated tumour microenvironment successfully induces systemic anti-tumour immunity.
    Eur J Cancer.2016 Jul;62:54-61. [ 27208904 ]

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