Detail for Ubiquitin Ligases


Full Name

Ubiquitin Ligases family

Gene Name

Multiple Targets

Related Disease

  • Glioblastoma [ref.1]

Therapy Method

Function

Ubiquitin ligases, critical to virtually all cellular signaling systems, alter the degradation or trafficking of most proteins in the cell, and indeed broad perturbation of this system, through inhibition of the proteosome, is a successful cancer treatment.
Ubiquitin ligases are knockdown by shRNA lead to apoptosis or cell cycle arrest in glioblastoma stem cells.
 
RNF25E3 ubiquitin-protein ligase RNF25; Q96BH1; NCBI ID: 64320
UBE3B: Ubiquitin-protein ligase E3B, Q7Z3V4;
 NCBI ID: 89910
DTX1E3 ubiquitin-protein ligase DTX1, Q86Y01; NCBI ID: 1840
UBE2E3: Ubiquitin-conjugating enzyme E2 E3, Q969T4; NCBI ID: 10477
RNF130E3 ubiquitin-protein ligase RNF130, Q86XS8; NCBI ID: 55819
NFX1: Transcriptional repressor NF-X1, Q12986; NCBI ID: 4799
CNOT4: CCR4-NOT transcription complex subunit 4, O95628; NCBI ID: 4850
TRIM3Tripartite motif-containing protein 3, O75382; NCBI ID: 10612
TRIM46Tripartite motif-containing protein 46, Q7Z4K8; NCBI ID: 80128
TRIM52: Tripartite motif-containing protein 52, Q96A61; NCBI ID: 84851
TRIM41E3 ubiquitin-protein ligase TRIM41, Q8WV44; NCBI ID: 90933
FBXO21F-box only protein 21, O94952; NCBI ID: 23014
MARCH9: E3 ubiquitin-protein ligase MARCH9, Q86YJ5; NCBI ID: 92979
FBXL20: F-box/LRR-repeat protein 20, Q96IG2; NCBI ID: 72194
FBXO44: F-box only protein 44, Q9H4M3; NCBI ID: 93611
PHF7: PHD finger protein7, Q9BWX1. NCBI ID: 51533

Reference

  • [1] Knockdown of ubiquitin ligases in glioblastoma cancer stem cells leads to cell death and differentiation.
    Low, J., et al. (2012). J Biomol Screen 17(2): 152-162.. [ 21956171 ]

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