Detail for CD45


Full Name

Receptor-type tyrosine-protein phosphatase C

Uniprot ID

Gene Name

PTPRC

NCBI ID

Related Disease

  • Orthotopic Bladder Cancer [ref.1]

Therapy Method

Function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.

Reference

  • [1] Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action.
    Arum, C. J., et al. (2011). J Biomed Opt 16(2): 028001.. [ 21361708 ]

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