Detail for ZEB1/ZEB2


Full Name

Zinc finger E-box-binding homeobox 1/2

Uniprot ID

Gene Name

ZEB1, ZEB2

NCBI ID

Related Disease

  • Head and Neck Cancer [ref.1]
  • Pancreatic Cancer [ref.2]

Therapy Method

Function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.

Related Pathway/CSCs feature

Reference

  • [1] Epithelial-mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer.
    Chu, P. Y., et al. (2013). Oral Oncol 49(1): 34-41.. [ 22892238 ]
  • [2] The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
    Wellner, U., et al. (2009). Nat Cell Biol 11(12): 1487-1495.. [ 19935649 ]

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