Detail for BMI1


Full Name

Polycomb complex protein BMI-1

Uniprot ID

Gene Name

BMI1

NCBI ID

Related Disease

  • Hepatocellular Carcinoma [ref.1]
  • Breast Cancer [ref.2]

Therapy Method

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Reference

  • [1] The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.
    Chiba, T., et al. (2008). Cancer Res 68(19): 7742-7749.. [ 18829528 ]
  • [2] Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells.
    Liu, S., et al. (2006). Cancer Res 66(12): 6063-6071.. [ 16778178 ]

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