Detail for TB-4


Full Name

Thymosin β-4

Uniprot ID

Gene Name

TMSB4X

NCBI ID

Related Disease

  • Breast Cancer [ref.1]

Therapy Method

Function

Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.

Related Pathway/CSCs feature

Reference

  • [1] Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population.
    Steiniger, S. C., et al. (2008). Stem Cells 26(12): 3037-3046.. [ 18802034 ]

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