Detail for ARTN


Full Name

Artemin

Uniprot ID

Gene Name

ARTN

NCBI ID

Related Disease

  • Breast Cancer [ref.1]

Therapy Method

Function

Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.

Related Pathway/CSCs feature

  • Radio- and Chemo-resistance

Reference

  • [1] Artemin stimulates radio- and chemo-resistance by promoting TWIST1-BCL-2-dependent cancer stem cell-like behavior in mammary carcinoma cells.
    Banerjee, A., et al. (2012). J Biol Chem 287(51): 42502-42515.. [ 23095743 ]

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