Detail for Snail


Full Name

Zinc finger protein SNAI1

Uniprot ID

Gene Name

SNAI1

NCBI ID

Related Disease

  • Head and Neck Squamous Cell Carcinoma [ref.1]
  • Colon Cancer [ref.2]

Therapy Method

Function

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Reference

  • [1] Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer.
    Chen, Y. C., et al. (2009). Biochem Biophys Res Commun 385(3): 307-313.. [ 19450560 ]
  • [2] Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells.
    Fan, F., et al. (2012). Cancer Med 1(1): 5-16.. [ 23342249 ]

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