Detail for β-Catenin


Full Name

Catenin beta-1

Uniprot ID

Gene Name

CTNNB1

NCBI ID

Related Disease

  • Ovarian Cancer [ref.1]
  • Hepatocellular Carcinoma [ref.2]
  • Esophageal Cancer [ref.3]

Therapy Method

Function

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.

Reference

  • [1] beta-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
    Condello, S., et al. (2014). Oncogene.. [ 24954508 ]
  • [2] beta-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid.
    Delgado, E., et al. (2013). Curr Cancer Drug Targets 13(8): 867-878.. [ 23822752 ]
  • [3] The radiosensitization effect of NS398 on esophageal cancer stem cell-like radioresistant cells.
    Che, S. M., et al. (2011). Dis Esophagus 24(4): 265-273.. [ 21087344 ]
  • [4] LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs.
    Al-Kharusi, M. R., et al. (2013). Carcinogenesis 34(5): 1150-1157.. [ 23349017 ]

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