Detail for Mcl-1


Full Name

Induced myeloid leukemia cell differentiation protein Mcl-1

Uniprot ID

Gene Name

MCL1

NCBI ID

Related Disease

  • Colon Cancer [ref.1]
  • Gastric Cancer [ref.2]

Therapy Method

Function

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Reference

  • [1] Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells.
    Timme, C. R., et al. (2013). Apoptosis 18(10): 1163-1174.. [ 23887890 ]
  • [2] Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells.
    Akagi, H., et al. (2013).Gastric Cancer 16(1): 100-110.. [ 22527182 ]

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