Detail for ETRA/ETRB


Full Name

Endothelin-A receptor, Endothelin-B receptor

Uniprot ID

Gene Name

EDNRA, EDNRB

NCBI ID

Related Disease

  • Ovarian Cancer [ref.1]

Therapy Method

Function

ETRA: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

ETRB: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Reference

  • [1] Endothelin receptor-A is required for the recruitment of antitumor T cells and modulates chemotherapy induction of cancer stem cells.
    Coffman, L., et al. (2013). Cancer Biol Ther 14(2): 184-192.. [ 23192269 ]

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