Detail for FOXM1


Full Name

Forkhead box protein M1

Uniprot ID

Gene Name

FOXM1

NCBI ID

Related Disease

  • Breast Cancer [ref.1]

Therapy Method

Function

Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.

Related Pathway/CSCs feature

  • resistance to endocrine treatments

Reference

  • [1] The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells.
    Bergamaschi, A., et al. (2014). Breast Cancer Res 16(5): 436.. [ 25213081 ]

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