Detail for Notch4


Full Name

Neurogenic locus notch homolog protein 4

Uniprot ID

Gene Name

NOTCH4

NCBI ID

Related Disease

  • Breast Cancer [ref.1, 2]

Therapy Method

Function

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system By similarity.

Related Pathway/CSCs feature

Reference

  • [1] Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.
    Harrison, H., et al. (2010). Cancer Res 70(2): 709-718.. [ 20068161 ]
  • [2] Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells.
    Dontu, G., et al. (2004). Breast Cancer Res 6(6): R605-615.. [ 15535842 ]

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