Detail for Notch3


Full Name

Neurogenic locus notch homolog protein 3

Uniprot ID

Gene Name

NOTCH3

NCBI ID

Related Disease

  • Breast Cancer [ref.1, 2]

Therapy Method

Function

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs By similarity.

Related Pathway/CSCs feature

Reference

  • [1] Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells.
    Debeb, B. G., et al. (2012). Breast Cancer Res Treat 134(2): 495-510.. [ 22547109 ]
  • [2] The lymphovascular embolus of inflammatory breast cancer exhibits a Notch 3 addiction.
    Xiao, Y., et al. (2011). Oncogene 30(3): 287-300.. [ 20838375 ]

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